T0070907, PPAR gamma antagonist (ab120876)
Key features and details
- Potent, selective PPARγ antagonist
- CAS Number: 313516-66-4
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
T0070907, PPAR gamma antagonist -
Description
Potent, selective PPARγ antagonist -
Biological description
Potent, selective PPARγ antagonist (IC50 = 1 nM). Antidiabetic actions in vivo. Inhibits rosiglitazone (ab120762). Blocks the recruitment of transcriptional cofactors to the PPARγ/RXR heterodimer. -
Purity
> 98% -
CAS Number
313516-66-4 -
Chemical structure
Properties
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Chemical name
2-Chloro-5-nitro-N-(4-pyridinyl)benzamide -
Molecular weight
277.67 -
Molecular formula
C12H8ClN3O3 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O -
Source
Synthetic
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Research areas
