Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor (ab144532)
Key features and details
- Potent, non-selective HDAC inhibitor
- CAS Number: 38937-66-5
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Suberoyl bis-hydroxamic acid (SBHA), HDAC inhibitor -
Description
Potent, non-selective HDAC inhibitor -
Biological description
Potent, non-selective HDAC inhibitor (ID50 values are 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively). Potentiates the cytostatic effects of 5-Fluorouracil (ab142387). Induces apoptosis. Shows antiproliferative effects (IC50 = 15 μM, HeLa cells). -
Purity
> 98% -
CAS Number
38937-66-5 -
Chemical structure
Properties
-
Chemical name
N,N′-Dihydroxyoctanediamide -
Molecular weight
204.23 -
Molecular formula
C8H16N2O4 -
PubChem identifier
5173 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C(CCCC(=O)NO)CCC(=O)NO -
Source
Synthetic
-
Research areas