Spiperone hydrochloride, 5-HT and D2-like receptor antagonist (ab120549)
Key features and details
- 5-HT and D2-like receptor antagonist
- CAS Number: 2022-29-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Spiperone hydrochloride, 5-HT and D2-like receptor antagonist -
Description
5-HT and D2-like receptor antagonist -
Biological description
5-HT and D2-like receptor antagonist. (IC50 values are 1.6 and 15 nM at 5-HT2 and 5-HT1C receptors, respectively. Ki values are 0.06 ( D2), 0.6 (D3), 0.08 (D4), ~ 350 (D1) and ~ 3500 nM (D5)). Potently enhances intracellular Ca2+ levels. Additionally activates Ca2+-activated Cl- channels (CaCC) to induce Cl- secretion.
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Purity
> 98% -
CAS Number
2022-29-9 -
Chemical structure
Images
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Functional Studies - Spiperone hydrochloride, 5-HT and D2-like receptor antagonist (ab120549) Odaka et al PLoS One. 2014 Jun 10;9(6):e99271. doi: 10.1371/journal.pone.0099271. eCollection 2014. Fig 2. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Cabergoline exerted neuroprotective effect via D2 receptor-mediated mechanism.
(Panel B) Spiperone inhibited neuroprotection by cabergoline. Spiperone (10 µM) was applied 20 mins before cabergoline (10 µM) treatment, followed by MTT assay. The data represent mean ± SD (n = 6–12). ***P2O2 - Caber - spiperone, †††P2O2 - Caber - spiperone (three-way ANOVA).