SMIFH2 Formin FH2 Domain Inhibitor (ab218296)
Key features and details
- Cell-permeable inhibitor of formin homology 2 (FH2) domains.
- CAS Number: 340316-62-3
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SMIFH2 Formin FH2 Domain Inhibitor -
Description
Cell-permeable inhibitor of formin homology 2 (FH2) domains. -
Alternative names
- Actin Assembly Inhibitor XV
- Small Molecule Inhibitor of Formin Homology 2 domain
- SMIFH2
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Biological description
Cell-permeable inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation (IC50 = ~15 µM) and processive barbed end elongation. Decreases the affinity of formin for the actin filament barbed end. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
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Purity
> 99% -
CAS Number
340316-62-3 -
Chemical structure
Properties
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Chemical name
1-(3-Bromophenyl)-5-(furan-2-ylmethylidene)-2-thioxopyrimidine-4,6(1H,5H)-dione -
Molecular weight
377.21 -
Molecular formula
C15H9BrN2O3S -
PubChem identifier
2258538 -
Storage instructions
Store at +4°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Brc1cccc(c1)N3C(=O)C(=Cc2ccco2)C(=O)NC3=S -
Source
Synthetic
