SKF 96365, TRP channel blocker (ab120280)
Key features and details
- Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
- CAS Number: 130495-35-1
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SKF 96365, TRP channel blocker -
Description
Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry. -
Biological description
Blocker of TRP cation channels. Inhibits capacitative Ca2+ entry.
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Purity
> 99% -
CAS Number
130495-35-1 -
Chemical structure
Images
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Functional Studies - SKF 96365, TRP channel blocker (ab120280) Sansone et al PLoS One. 2014; 9(1): e87721. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
TRP channel blockers affect most of the L-arginine-induced responses.
L-arginine-induced Ca2+ responses of two ORNs of another individual slice of the lateral MOE (cyan and red trace). Incubation with SKF-96365 (80 µM; 10 min; lilac-shaded panel) led to a strong reduction of the Ca2+ transient in only one of the two ORNs (red trace). The response of the affected ORN recovered after 10 min of washout (right-hand traces). ORNs unaffected and affected by SKF-96365, expressed as percentage of total ORNs tested (histogram; 25 cells, 4 slices).
(From Figure 5C of Sansone et al).
