Simocyclinone D8, Topoisomerase I and II inhibitor (ab144362)
Key features and details
- Topoisomerase I and II inhibitor. Potent DNA gyrase inhibitor. Antibiotic agent.
- CAS Number: 301845-97-6
- Purity: > 97%
- Soluble in DMSO
- Form / State: Solid
- Source: Streptomyces antibioticus
Overview
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Product name
Simocyclinone D8, Topoisomerase I and II inhibitor -
Description
Topoisomerase I and II inhibitor. Potent DNA gyrase inhibitor. Antibiotic agent. -
Biological description
Topoisomerase I and II inhibitor (IC50 = 100 μM). Potent DNA gyrase inhibitor. Antibiotic agent. Inhibits topoisomerase II without inducing DNA strands breaks. Shows antiproliferative effects against cancer cell lines (IC50 values are 75-125 μM for NSCLC cells). -
Purity
> 97% -
CAS Number
301845-97-6 -
Chemical structure
Properties
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Molecular weight
932.27 -
Molecular formula
C46H42ClNO18 -
PubChem identifier
54736483 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1[C@H]([C@@H](C[C@@H](O1)C2=C(C3=C(C=C2)C(=O)[C@]45[C@]([C@@H]3O)(O4)[C@H](C[C@]6([C@@]5(C(=O)C=C(C6)C)O)O)O)O)OC(=O)/C=C/C=C/C=C/C=C/C(=O)NC7=C(C8=C(C(=C(C=C8)O)Cl)OC7=O)O)OC(=O)C -
Source
Streptomyces antibioticus
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Research areas