Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068)
Key features and details
- Selective serotonin reuptake inhibitor
- CAS Number: 79559-97-0
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Sertraline hydrochloride, Serotonin reuptake inhibitor -
Description
Selective serotonin reuptake inhibitor -
Biological description
Selective serotonin reuptake inhibitor (Ki = 2.0 μM). Shows antidepressant and antiproliferative activity. Active in vivo.
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Purity
> 99% -
CAS Number
79559-97-0 -
Chemical structure
Properties
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Chemical name
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride -
Molecular weight
342.69 -
Molecular formula
C17H17Cl2N.HCl -
PubChem identifier
54375 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc1ccc(cc1Cl)[C@@H]3CC[C@H](NC)c2ccccc23 -
Source
Synthetic
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Research areas
Images
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Functional Studies - Sertraline hydrochloride, Serotonin reuptake inhibitor (ab141068)ab1223 staining transferrin in HeLa cells treated with sertraline hydrochloride (ab141068), by ICC/IF. Decrease in transferrin expression correlates with increased concentration of sertraline hydrochloride, as described in literature.
The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab141068 (sertraline hydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab1223 (1/500 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
