Scriptaid, HDAC inhibitor (ab120883)
Key features and details
- HDAC inhibitor
- CAS Number: 287383-59-9
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Scriptaid, HDAC inhibitor -
Description
HDAC inhibitor -
Biological description
Novel HDAC inhibitor, able to cause >100-fold increase in histone deacetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo. -
Purity
> 98% -
CAS Number
287383-59-9 -
Chemical structure
Properties
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Chemical name
N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide -
Molecular weight
326.35 -
Molecular formula
C18H18N2O4 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(C1=CC=CC2=C1C3=CC=C2)N(CCCCCC(NO)=O)C3=O -
Source
Synthetic
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Research areas
Images
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Functional Studies - Scriptaid, HDAC inhibitor (ab120883)ab10812 staining histone H3 (acetyl K9) in A549 cells treated with scriptaid (ab120883), by ICC/IF. Increase in histone H3 (acetyl K9) expression correlates with increased concentration of scriptaid, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab120883 (scriptaid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab10812 (0.1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.