SB 269970 hydrochloride, 5-HT7 receptor antagonist (ab120508)
Key features and details
- Potent, selective 5-HT7 receptor antagonist
- CAS Number: 261901-57-9
- Purity: > 98%
- Soluble in water to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SB 269970 hydrochloride, 5-HT7 receptor antagonist -
Description
Potent, selective 5-HT7 receptor antagonist -
Biological description
Potent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant in vivo.
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Purity
> 98% -
CAS Number
261901-57-9 -
Chemical structure
Properties
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Chemical name
3-[[(2R)-2-[2-(4-Methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]phenol hydrochloride -
Molecular weight
388.95 -
Molecular formula
C18H28N2O3S.HCl -
PubChem identifier
11957684 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl -
Source
Synthetic
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Research areas
