VE-821, ATP competitive ATR inhibitor (ab219506)
Key features and details
- Potent, selective ATP competitive ATR inhibitor
- CAS Number: 1232410-49-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
VE-821, ATP competitive ATR inhibitor -
Description
Potent, selective ATP competitive ATR inhibitor -
Alternative names
- ATR Inhibitor IV
- VE 821
- VE821
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Biological description
Potent, selective ATP competitive ATR inhibitor (Ki = 13 nM). Exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. Decreases phosphorylation of Chk1 and increases sensitivity of pancreatic cancer cells and leukemia cells to radiation.
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Purity
> 98% -
CAS Number
1232410-49-9 -
Chemical structure
Properties
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Chemical name
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide -
Molecular weight
368.41 -
Molecular formula
C18H16N4O3S -
PubChem identifier
51000408 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N -
Source
Synthetic
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Research areas
