SANT-2, Smoothened receptor antagonist (ab141481)
Key features and details
- Potent smoothened receptor antagonist
- CAS Number: 329196-48-7
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
SANT-2, Smoothened receptor antagonist -
Description
Potent smoothened receptor antagonist -
Biological description
Potent smoothened receptor antagonist. Allosteric modulation similar to SANT-1 (ab141483). Able to displace smo- [3H]SAG-1.3 and [3H]Cyclopamine binding (Ki values are 7.8 and 8.4 nM respectively). -
Purity
> 95% -
CAS Number
329196-48-7 -
Chemical structure
Properties
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Chemical name
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide -
Molecular weight
479.96 -
Molecular formula
C26H26ClN3O4 -
PubChem identifier
1367095 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC(=C(C=C2)Cl)C3=NC4=CC=CC=C4N3 -
Source
Synthetic
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Research areas