(S)-Cotinine, nicotine metabolite (ab144813)
Key features and details
- Major metabolite of nicotine in humans. Activates, and desensitizes neuronal nicotinic acetylcholine receptors.
- CAS Number: 486-56-6
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
(S)-Cotinine, nicotine metabolite -
Description
Major metabolite of nicotine in humans. Activates, and desensitizes neuronal nicotinic acetylcholine receptors. -
Alternative names
- (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
- (S)-(-)-1-Methyl-5-(3-pyridiyl)-2-
- (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone
see all -
Biological description
Major metabolite of nicotine in humans. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model. Activates a subpopulation of α3/α6β2 nAChRs in monkey striatum.
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CAS Number
486-56-6 -
Chemical structure
Properties
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Chemical name
(5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone -
Molecular weight
176.22 -
Molecular formula
C10H12N2O -
Storage instructions
Store at +4°C. -
Handling
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Source
Synthetic
