Ryuvidine (ab254235)
Key features and details
- Inhibitor of KMT5A / SETD8 / Pr-SET7 that blocks H4K20 monomethylation.
- CAS Number: 265312-55-8
- Purity: > 98%
DMSO: 5 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ryuvidine -
Description
Inhibitor of KMT5A / SETD8 / Pr-SET7 that blocks H4K20 monomethylation. -
Alternative names
- 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
- Cdk4 Inhibitor III
- Cyclic-dependent Kinase 4 Inhibitor III
- SPS812
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Biological description
Inhibits (IC50 = 500 nM) KMT5A / SETD8 / Pr-SET7 and suppresses H4JK20 monomethylation in vitro. Weakly active against Cdk4 (IC50 = 6 μM). Induces S-phase accumulation in HEK-293 cells. Cytotoxic towards a number of human cancer cell lines. May induce the DNA damage response.
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Purity
> 98% -
General notes
Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from air and light.
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CAS Number
265312-55-8 -
Chemical structure
Properties
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Chemical name
2-Methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione
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Molecular weight
284.33 -
Molecular formula
C15H12N2O2S -
PubChem identifier
481747 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. -
Solubility overview
DMSO: 5 mg/ml
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)N=C(S3)C -
Source
Synthetic
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Research areas
