RS 102895 hydrochloride, CCR2 receptor antagonist (ab120812)
Key features and details
- Selective CCR2 receptor antagonist
- CAS Number: 1173022-16-6
- Purity: > 99%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
RS 102895 hydrochloride, CCR2 receptor antagonist -
Description
Selective CCR2 receptor antagonist -
Biological description
Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
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Purity
> 99% -
CAS Number
1173022-16-6 -
Chemical structure
Properties
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Chemical name
1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride -
Molecular weight
426.86 -
Molecular formula
C21H21F3N2O2.HCl -
PubChem identifier
16759153 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl -
Source
Synthetic