Ro 25-6981 maleate salt (mM/ml), NR2B antagonist (ab146695)
Key features and details
- NR2B antagonist. 1 ml water soluble pack.
- CAS Number: 169274-78-6
- Purity: > 98%
- Soluble in 1ml of water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ro 25-6981 maleate salt (mM/ml), NR2B antagonist -
Description
NR2B antagonist. 1 ml water soluble pack. -
Biological description
Potent, highly selective, activity-dependent blocker of NMDA receptors that contain the NR2B subunit (IC50 values are 0.009 and 52 μM at NR1C/NR2B and NR1C/NR2A, respectively). Displays no significant activity at kainate/AMPA receptors, Na+ and Ca2+ channels at concentrations showing maximal protection in neurotoxicity tests. Neuroprotective actions in vivo and in vitro.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
Purity
> 98% -
CAS Number
169274-78-6 -
Chemical structure
Properties
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Chemical name
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate -
Molecular weight
455.55 -
Molecular formula
C22H29NO2.C4H4O4 -
PubChem identifier
53250677 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1ml of water to give specified mM/ml concentration -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)/C=CC(=O)O.Oc1ccc(cc1)[C@H](O)[C@@H](C)CN2CCC(CC2)Cc3ccccc3 -
Source
Synthetic
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Research areas
