Regorafenib, multikinase inhibitor (ab216314)
Key features and details
- Potent multikinase inhibitor
- CAS Number: 755037-03-7
Soluble in DMSO (>50mg/ml). Slightly soluble in ethanol (1mg/ml). Insoluble in water.
- Form / State: Solid
Overview
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Product name
Regorafenib, multikinase inhibitor -
Description
Potent multikinase inhibitor -
Alternative names
- BAY 73-4506
- Fluoro-Sorafenib
- Stivarga
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Biological description
Potent multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent.
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CAS Number
755037-03-7 -
Chemical structure
Properties
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Chemical name
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
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Molecular weight
482.82 -
Molecular formula
C21H15ClF4N4O3 -
PubChem identifier
11167602 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO (>50mg/ml). Slightly soluble in ethanol (1mg/ml). Insoluble in water.
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SMILES
CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
