Recombinant Rabbit IL-4 protein (ab101327)
Key features and details
- Expression system: Yeast
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
-
Product name
Recombinant Rabbit IL-4 protein
See all IL-4 proteins and peptides -
Purity
> 95 % SDS-PAGE.
ab101327 was purified by ion-exchange chromatography -
Expression system
Yeast -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
-
Species
Rabbit -
Sequence
GRRGDIILPE VIKTLNILTE RKTPCTKLMI ADALAVPKNT TEREAVCRAA TALRQFYLHH KVSWCFKEHG ELGDLRLLRG LDRNLCSMAK LSNCPGKEAR QTTLEDFLDR LKTAMQEKYS KRQS -
Predicted molecular weight
14 kDa -
Amino acids
24 to 147
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Preparation and Storage
-
Alternative names
- B cell growth factor 1
- B cell IgG differentiation factor
- B Cell Stimulatory Factor 1
see all -
Function
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. -
Involvement in disease
Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. -
Sequence similarities
Belongs to the IL-4/IL-13 family. -
Cellular localization
Secreted. - Information by UniProt
