Recombinant Mouse TWEAK protein (ab184591)
Key features and details
- Expression system: Yeast
- Suitable for: SDS-PAGE, ELISA, WB
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Product name
Recombinant Mouse TWEAK protein
See all TWEAK proteins and peptides -
Expression system
Yeast -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
SAPKGRKARP RRAIAAHYEV HPRPGQDGAQ AGVDGTVSGW EETKINSSSP LRYDRQIGEF TVIRAGLYYL YCQVHFDEGK AVYLKLDLLV NGVLALRCLE EFSATAASSP GPQLRLCQVS GLLPLRPGSS LRIRTLPWAH LKAAPFLTYF GLFQVH -
Predicted molecular weight
17 kDa -
Amino acids
94 to 249 -
Additional sequence information
Amino acids 94 to 249 represent the chain for the secreted form of mouse TWEAK.
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Preparation and Storage
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Alternative names
- APO 3 ligand
- APO 3L
- APO3 ligand
see all -
Function
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. -
Tissue specificity
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. -
Sequence similarities
Belongs to the tumor necrosis factor family. -
Post-translational
modificationsThe soluble form derives from the membrane form by proteolytic processing. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
