Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Escherichia coli
Purity: > 95% SDS-PAGE
Endotoxin level:
Suitable for: SDS-PAGE

Product name

Recombinant Mouse LIGHT/TNFSF14 protein
See all LIGHT/TNFSF14 proteins and peptides
Purity

> 95 % SDS-PAGE.
Greater than 98% by SDS-PAGE and HPLC analyses.
Endotoxin level
Expression system

Escherichia coli
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Mouse
- Sequence
  
  MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV

Our Abpromise guarantee covers the use of ab50095 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications

SDS-PAGE
Form

Lyophilized
Additional notes

This product was previously labelled as LIGHT
Concentration information loading...

Stability and Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4oC for 1 week or -20oC for future use.

Alternative names
- CD 258
- CD258
- CD258 antigen
- Delta transmembrane LIGHT
- Herpes virus entry mediator ligand
- Herpesvirus entry mediator A
- Herpesvirus entry mediator ligand
- herpesvirus entry mediator-ligand
- HVEM L
- HVEM-L
- HVEML
- Ligand for herpesvirus entry mediator
- LIGHT
- LTg
- soluble form
- TNF14
- TNF14_HUMAN
- TNFSF 14
- Tnfsf14
- TNFSF14 protein
- TR 2
- TR2
- Tumor necrosis factor (ligand) superfamily, member 14
- Tumor necrosis factor ligand superfamily member 14
- Tumor necrosis factor ligand superfamily, member 14
- Tumor necrosis factor receptor like 2
- tumor necrosis factor receptor-like 2
- Tumor necrosis factor superfamily member 14
- Tumor necrosis factor superfamily member LIGHT
see all
Function

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Tissue specificity

Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Sequence similarities

Belongs to the tumor necrosis factor family.
Post-translational
modifications

N-glycosylated.
The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
Cellular localization

Cytoplasm; Secreted and Cell membrane.
Target information above from: UniProt accession O43557 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols