Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant mouse IL-2 protein (ab9856)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant mouse IL-2 protein
    See all IL-2 proteins and peptides

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      Recombinant Murine IL-2 is a 17.2 kDa protein containing 149 amino acid residues: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDL QELLSR MENYRNLKLP RMLTFKFYLPKQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQFDDESAT VVD FLRRWIAFCQ SIISTSPQ

    • Associated products

      Specifications

      Our Abpromise guarantee covers the use of ab9856 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      • Applications

        Functional Studies

        SDS-PAGE

      • Form

        Lyophilized

      • Additional notes

        The ED50, determined by the dose-dependent stimulation of murine CTLL-2 cells, is 5 x 106 units/mg.
      • Concentration information loading...

      Preparation and Storage

      • Stability and Storage

        Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

        This product is an active protein and may elicit a biological response in vivo, handle with caution.

      • Reconstitution
        Please reconstitute this product in 200ul sterile water.

      General Info

      • Alternative names

        • Aldesleukin
        • IL 2
        • IL-2
        • IL2
        • IL2_HUMAN
        • Interleukin 2
        • Interleukin-2
        • interleukin2
        • Involved in regulation of T cell clonal expansion
        • Lymphokine
        • OTTHUMP00000164090
        • POIL2
        • T Cell Growth Factor
        • T-cell growth factor
        • TCGF
        see all

      • Function

        Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

      • Involvement in disease

        Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

      • Sequence similarities

        Belongs to the IL-2 family.

      • Cellular localization

        Secreted.
      • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (1)

    Publishing research using ab9856? Please let us know so that we can cite the reference in this datasheet.

    ab9856 has been referenced in 1 publication.

    • Burr ML  et al. An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell 36:385-401.e8 (2019). PubMed: 31564637

    Preparation and Storage

    • Alternative names

      • Aldesleukin
      • IL 2
      • IL-2
      • IL2
      • IL2_HUMAN
      • Interleukin 2
      • Interleukin-2
      • interleukin2
      • Involved in regulation of T cell clonal expansion
      • Lymphokine
      • OTTHUMP00000164090
      • POIL2
      • T Cell Growth Factor
      • T-cell growth factor
      • TCGF
      see all

    • Function

      Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

    • Involvement in disease

      Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

    • Sequence similarities

      Belongs to the IL-2 family.

    • Cellular localization

      Secreted.
    • Information by UniProt

    Images

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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