Recombinant mouse IL-1RA protein (ab119723)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant mouse IL-1RA protein
See all IL-1RA proteins and peptides -
Biological activity
ab119723 is capable of inhibiting IL-1 alpha activity in helper T cell line D10.G4.1.
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Purity
> 98 % SDS-PAGE.
ab119723 was purified by proprietary chromatographic techniques and Gel Filtration. Purity: > 98 % by SDS-PAGE -
Expression system
Escherichia coli -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Mouse -
Sequence
The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Cys-Arg-Pro-Ser-Gly. -
Predicted molecular weight
17 kDa -
Amino acids
25 to 178
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Preparation and Storage
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Alternative names
- DIRA
- F630041P17Rik
- ICIL 1RA
see all -
Function
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. -
Tissue specificity
The intracellular form of IL1RN is predominantly expressed in epithelial cells. -
Involvement in disease
Microvascular complications of diabetes 4
Interleukin 1 receptor antagonist deficiency -
Cellular localization
Cytoplasm and Secreted. - Information by UniProt
