Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Mouse DR6 protein (ab109063)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Mouse DR6 protein
    See all DR6 proteins and peptides

  • Purity

    > 95 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    Q9EPU5

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Predicted molecular weight

      80 kDa

    • Amino acids

      42 to 348

    • Specifications

    Our Abpromise guarantee covers the use of ab109063 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized

    • Additional notes

      PBS containing at least 0.1% BSA should be used for further dilutions.
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

      Constituent: PBS

    • Reconstitution
      Reconstitute with 50 µl sterile water.

    General Info

    • Alternative names

      • TNFRSF 21
      • BM 018
      • BM018
      • CD358
      • Death receptor 6
      • DR 6
      • DR6
      • MGC31965
      • OTTHUMP00000039915
      • TNFR related death receptor 6
      • TNFRSF21
      • TNFRSF21 protein
      • TNR21_HUMAN
      • Tumor necrosis factor receptor superfamily member 21
      • Tumor necrosis factor receptor superfamily member 21 precursor
      see all

    • Function

      May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

    • Tissue specificity

      Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

    • Sequence similarities

      Contains 1 death domain.
      Contains 4 TNFR-Cys repeats.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab109063? Please let us know so that we can cite the reference in this datasheet.

ab109063 has not yet been referenced specifically in any publications.

Preparation and Storage

  • TNFRSF 21
  • BM 018
  • BM018

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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