Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Mouse CD74 protein (Fc Chimera) (ab214606)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Mouse CD74 protein (Fc Chimera)
    See all CD74 proteins and peptides

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    HEK 293 cells

  • Accession

    P04441-2

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Mouse

    • Sequence

      QQQGR LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL EEKKPTEAPP KEPLDMEDLS SGLGVTRQEL GQVTL

    • Predicted molecular weight

      55 kDa including tags

    • Amino acids

      56 to 215

    • Additional sequence information

      The extracellular domain of mouse CD74 (aa 56-215) Short Isoform is fused to the N-terminus of the Fc region of mouse IgG2a (NP_034675.1).

    • Specifications

    Our Abpromise guarantee covers the use of ab214606 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. Stable for 12 months at -20°C.

      Constituent: 100% PBS

      Lyophilized from 0.2µm-filtered solution

    • Reconstitution
      Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

    General Info

    • Alternative names

      • CD 74
      • CD74
      • CD74 antigen
      • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
      • CD74 molecule
      • CD74 molecule, major histocompatibility complex, class II invariant chain
      • CLIP
      • DHLAG
      • Gamma chain of class II antigens
      • HG2A_HUMAN
      • HLA class II histocompatibility antigen gamma chain
      • HLA DR antigens associated invariant chain
      • HLA DR gamma
      • HLA-DR antigens-associated invariant chain
      • HLA-DR-gamma
      • HLADG
      • HLADR antigens associated invariant chain
      • Ia antigen associated invariant chain
      • Ia antigen-associated invariant chain
      • Ia associated invariant chain
      • Ia gamma
      • Ii
      • Invariant polypeptide of major histocompatibility complex class II antigen associated
      • la-gamma
      • Major histocompatibility complex class II invariant chain
      • MHC HLA DR gamma chain
      • MHC HLA-DR gamma chain
      • p33
      • p35
      • Protein 41
      see all

    • Function

      Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

    • Sequence similarities

      Contains 1 thyroglobulin type-1 domain.

    • Cellular localization

      Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214606? Please let us know so that we can cite the reference in this datasheet.

ab214606 has not yet been referenced specifically in any publications.

Preparation and Storage

  • CD 74
  • CD74
  • CD74 antigen

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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