Recombinant Mouse BTNL2 protein (Fc Chimera) (ab214559)
Key features and details
- Expression system: CHO cells
- Purity: >= 98% SDS-PAGE
- Endotoxin level:
- Suitable for: SDS-PAGE
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Product name
Recombinant Mouse BTNL2 protein (Fc Chimera) -
Purity
>= 98 % SDS-PAGE. -
Endotoxin level
Expression system
CHO cellsAccession
Protein length
Protein fragmentAnimal free
NoNature
Recombinant-
Species
Mouse -
Amino acids
26 to 457 -
Additional sequence information
Recombinant fragment of Isoform 2 fused to the N-terminus of the Fc region of mouse IgG2a.
Specifications
Our Abpromise guarantee covers the use of ab214559 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped at 4°C. Store at -20°C long term. Avoid freeze / thaw cycle.
Constituent: 100% PBS
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ReconstitutionReconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.
General Info
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Alternative names
- BTL-II
- Btnl2
- BTNL2_HUMAN
see all -
Function
Negative regulator of T cell proliferation. -
Tissue specificity
Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus. -
Involvement in disease
Genetic variation in BTNL2 is a cause of susceptibility to sarcoidosis type 2 (SS2) [MIM:612387]. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis. -
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 3 Ig-like V-type (immunoglobulin-like) domains. -
Cellular localization
Membrane. Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound. - Information by UniProt
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab214559 has not yet been referenced specifically in any publications.
Preparation and Storage
- BTL-II
- Btnl2
- BTNL2_HUMAN
