Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human TNFRSF14/HVEM protein (Biotin) (ab198632)

Key features and details

Expression system: HEK 293 cells
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies

Alternative names
- HVEML
- ATAR
- CD270
- CD40 like protein precursor
- Herpes virus entry mediator A
- Herpesvirus entry mediator
- Herpesvirus entry mediator A
- Herpesvirus entry mediator ligand
- HveA
- HVEM
- HVEM L
- LIGHT
- LIGHTR
- TNFRSF14
- TNFSF 14
- TNR14_HUMAN
- TR2
- Tumor necrosis factor receptor like gene2
- Tumor necrosis factor receptor superfamily member 14
- Tumor necrosis factor receptor superfamily member 14 precursor
- Tumor necrosis factor receptor-like 2
see all
Function

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Tissue specificity

Widely expressed, with the highest expression in lung, spleen and thymus.
Sequence similarities

Contains 3 TNFR-Cys repeats.
Post-translational
modifications

N-glycosylated.
Cellular localization

Membrane.
Target information above from: UniProt accession Q92956 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant human TNFRSF14/HVEM protein (Biotin) (ab198632)

4-20% SDS-PAGE with Coomassie stain
Lane 1: 2 µg ab198632
Lane 2: Protein marker
Functional Studies - Recombinant human TNFRSF14/HVEM protein (Biotin) (ab198632)

BTLA:TNFRSF14/HVEM binding activity, measured using an Inhibitor Screening Assay Kit.

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