Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human TIGAR protein (ab115509)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant Human TIGAR protein
    See all TIGAR proteins and peptides

  • Purity

    > 95 % SDS-PAGE.
    ab115509 is greater than 95% by SDS-PAGE gel and HPLC analyses.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    Q9NQ88

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      ARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKF THAFSSDLMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALS ELRAMAKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKE QFSQGSPSNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVVSHGAY MRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFIINFEEGREVKPT VQCICMNLQDHLNGLTETRGGGYGRKKRRQRRR

    • Predicted molecular weight

      36 kDa including tags

    • Amino acids

      1 to 270

    • Specifications

    Our Abpromise guarantee covers the use of ab115509 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

    • Form

      Lyophilized

    • Additional notes

      Pretreatment with ab115509 for 4 hrs, using a concentration range 0.1-5.0 µg/ml, protects U2OS cells from apoptosis induced by hydrogen peroxide.
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    • Reconstitution
      For lot specific reconstitution information please contact our Scientific Support Team.

    General Info

    • Alternative names

      • 6-bisphosphatase TIGAR
      • C12ORF5
      • chromosome 12 open reading frame 5
      • FR2BP
      • Fructose-2,6-bisphosphatase TIGAR
      • Fructose-2,6-bisphosphate 2-phosphatase
      • Probable fructose 2,6 bisphosphatase TIGAR
      • Probable fructose-2
      • tigar
      • TIGAR_HUMAN
      • TP53 induced glycolysis and apoptosis regulator
      • TP53 induced glycolysis regulatory phosphatase
      • TP53-induced glycolysis and apoptosis regulator
      • Transactivated by NS3TP2 protein
      see all

    • Function

      Probable fructose-biphosphatase. Lowers cellular levels of fructose 2,6-bisphosphate. Protects cells against reactive oxygen species and against apoptosis induced by p53/TP53.

    • Sequence similarities

      Belongs to the phosphoglycerate mutase family.

    • Post-translational
      modifications

      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab115509? Please let us know so that we can cite the reference in this datasheet.

ab115509 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    For lot specific reconstitution information please contact our Scientific Support Team.

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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