Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human Thymosin beta 4 protein (Active) (ab245823)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies, HPLC

Description

  • Product name

    Recombinant human Thymosin beta 4 protein (Active)
    See all Thymosin beta 4 proteins and peptides

  • Biological activity

    Pretreatment of primary lung fibroblasts with recombinant Thymosin-β4, using a concentration of 0.5 - 10 μg/ml, produces a protective effect against hydrogen peroxide induced cell death.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    P62328

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      RMSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES

    • Predicted molecular weight

      5 kDa

    • Amino acids

      1 to 44

    • Specifications

    Our Abpromise guarantee covers the use of ab245823 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

      Functional Studies

      HPLC

    • Form

      Lyophilized

    • Additional notes

      Human, mouse and rat Thymosin beta 4 proteins are identical in sequence.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute in water to 0.1 - 1.0 mg/ml.

    General Info

    • Alternative names

      • Fx
      • Hematopoietic system regulatory peptide
      • Prothymosin beta 4
      • PTMB 4
      • PTMB4
      • Seraspenide
      • T beta 4
      • T beta-4
      • TB4X
      • THYB 4
      • Thyb4
      • Thymosin beta 4
      • Thymosin beta 4 X chromosome
      • Thymosin beta 4 X linked
      • TMSB 4
      • TMSB4
      • Tmsb4x
      • TYB4_HUMAN
      see all

    • Function

      Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
      Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase.

    • Tissue specificity

      Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.

    • Sequence similarities

      Belongs to the thymosin beta family.

    • Cellular localization

      Cytoplasm > cytoskeleton.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab245823? Please let us know so that we can cite the reference in this datasheet.

ab245823 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • Reconstitution
    Reconstitute in water to 0.1 - 1.0 mg/ml.

Images

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