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Recombinant Human PLGF protein (ab269160)

Key features and details

  • Expression system: Escherichia coli
  • Endotoxin level:
  • Suitable for: SDS-PAGE

Preparation and Storage

  • Alternative names

    • D12S1900
    • Pgf
    • PGFL
    • PIGF
    • Placenta growth factor
    • Placental growth factor
    • Placental growth factor, vascular endothelial growth factor related protein
    • PlGF
    • PlGF 2
    • PLGF_HUMAN
    • PlGF2
    • SHGC 10760
    see all

  • Function

    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.

  • Tissue specificity

    While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.

  • Sequence similarities

    Belongs to the PDGF/VEGF growth factor family.

  • Domain

    Isoform PlGF-2 contains a basic insert which acts as a cell retention signal.

  • Post-translational
    modifications

    N-glycosylated.

  • Cellular localization

    Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human PLGF protein (ab269160)
    SDS-PAGE - Recombinant Human PLGF protein (ab269160)
    SDS-PAGE analysis of ab269160 at 1ug/lane under (-) non-reducing and (+) reducing conditions. 4-20% Tris glycine gel. Stained with coomassie blue.

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