Recombinant human PD1 protein (Tagged) (ab271665)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Suitable for: SDS-PAGE
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Product name
Recombinant human PD1 protein (Tagged)
See all PD1 proteins and peptides -
Biological activity
Assay Conditions: a sample containing europium-labeled (Eu) PD-1, dye-labeled acceptor, biotin-labeled PD-L1, and an inhibitor is incubated for two hours. Then, the fluorescence intensity of inhibition of Human PD-1 binding to Human PD-L1 is measured using a fluorescence reader.
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Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ -
Predicted molecular weight
43 kDa including tags -
Amino acids
25 to 167 -
Additional sequence information
Europium-labeled fused at the C-terminus to the Fc portion of human IgG1
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Preparation and Storage
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Alternative names
- CD279
- CD279 antigen
- hPD 1
see all -
Function
Possible cell death inducer, in association with other factors. -
Involvement in disease
Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Developmental stage
Induced at programmed cell death. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human PD1 protein (Tagged) (ab271665)
SDS-PAGE analysis of ab271665.
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Functional Studies - Recombinant human PD1 protein (Tagged) (ab271665)Specific activity of ab271665.