Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human PD1 protein (Tagged) (ab271665)

Key features and details

Expression system: HEK 293 cells
Purity: >= 90% SDS-PAGE
Active: Yes
Suitable for: SDS-PAGE

Product name

Recombinant human PD1 protein (Tagged)
See all PD1 proteins and peptides
Biological activity

Assay Conditions: a sample containing europium-labeled (Eu) PD-1, dye-labeled acceptor, biotin-labeled PD-L1, and an inhibitor is incubated for two hours. Then, the fluorescence intensity of inhibition of Human PD-1 binding to Human PD-L1 is measured using a fluorescence reader.
Purity

>= 90 % SDS-PAGE.
Expression system

HEK 293 cells
Accession

Q15116
Protein length

Protein fragment
Animal free

No
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ
- Predicted molecular weight
  
  43 kDa including tags
- Amino acids
  
  25 to 167
- Additional sequence information
  
  Europium-labeled fused at the C-terminus to the Fc portion of human IgG1

Alternative names
- CD279
- CD279 antigen
- hPD 1
- hPD l
- hPD-1
- hSLE1
- PD 1
- PD-1
- PD1
- PDCD 1
- PDCD1
- PDCD1_HUMAN
- Programmed cell death 1
- Programmed cell death 1 protein
- Programmed cell death protein 1
- Protein PD 1
- Protein PD-1
- SLEB2
- Systemic lupus erythematosus susceptibility 2
see all
Function

Possible cell death inducer, in association with other factors.
Involvement in disease

Genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2 (SLEB2) [MIM:605218]. Systemic lupus erythematosus is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Developmental stage

Induced at programmed cell death.
Cellular localization

Membrane.
Target information above from: UniProt accession Q15116 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

SDS-PAGE - Recombinant Human PD1 protein (Tagged) (ab271665)

SDS-PAGE analysis of ab271665.
Functional Studies - Recombinant human PD1 protein (Tagged) (ab271665)

Specific activity of ab271665.

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