Antibodies, Proteins, Kits and Reagents for Life Science

Recombinant human p75 NGF Receptor protein (ab157276)

Key features and details

Expression system: HEK 293 cells
Purity: > 95% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: Functional Studies, SDS-PAGE

Alternative names
- CD271
- CD271 antigen
- Gp80 LNGFR
- Gp80-LNGFR
- Low affinity nerve growth factor receptor
- Low affinity neurotrophin receptor p75NTR
- Low-affinity nerve growth factor receptor
- Nerve growth factor receptor
- Nerve growth factor receptor TNFR superfamily member 16
- NGF receptor
- Ngfr
- p75 ICD
- p75 Neurotrophin receptor
- p75 NTR
- p75(NTR)
- p75NTR
- TNFR Superfamily Member 16
- TNFRSF16
- TNR16_HUMAN
- Tumor necrosis factor receptor superfamily member 16
see all
Function

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Sequence similarities

Contains 1 death domain.
Contains 4 TNFR-Cys repeats.
Domain

Death domain is responsible for interaction with RANBP9.
The extracellular domain is responsible for interaction with NTRK1.
Post-translational
modifications

N- and O-glycosylated.
O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.
Cellular localization

Membrane.
Target information above from: UniProt accession P08138 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

Functional Studies - Recombinant human p75 NGF Receptor protein (ab157276)

Neurite induction test using ab157276.

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