• Product name

  Recombinant Human p38 delta/MAPK13 protein
  See all p38 delta/MAPK13 proteins and peptides

• Expression system

  Baculovirus infected Sf9 cells

• Protein length

  Full length protein

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

• Alternative names

  • MAP kinase 13
  • MAP kinase p38 delta
  • MAPK 13

  • MAPK-13
  • Mapk13
  • MGC99536
  • Mitogen activated protein kinase 13
  • Mitogen-activated protein kinase 13
  • Mitogen-activated protein kinase p38 delta
  • MK13_HUMAN
  • OTTHUMP00000016282
  • OTTHUMP00000016283
  • p38 delta
  • P38delta
  • PRKM13
  • SAPK 4
  • SAPK4
  • Stress activated protein kinase 4
  • Stress-activated protein kinase 4

  see all

• Function

  Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K.

• Tissue specificity

  Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.

• Sequence similarities

  Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
  Contains 1 protein kinase domain.

• Domain

  The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

• Post-translational
  modifications

  Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.

• Target information above from: UniProt accession O15264 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt