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Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 80% SDS-PAGE
  • Tags: His tag C-Terminus
  • Suitable for: SDS-PAGE, WB, ELISA

Description

  • Product name

    Recombinant Human Ornithine Carbamoyltransferase/OTC protein
    See all Ornithine Carbamoyltransferase/OTC proteins and peptides

  • Purity

    > 80 % SDS-PAGE.

  • Expression system

    Escherichia coli

  • Accession

    P00480

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MLFNLRILLN NAAFRNGHNF MVRNFRCGQP LQNKVQLKGR DLLTLKNFTG EEIKYMLWLS ADLKFRIKQK GEYLPLLQGK SLGMIFEKRS TRTRLSTETG FALLGGHPCF LTTQDIHLGV NESLTDTARV LSSMADAVLA RVYKQSDLDT LAKEASIPII NGLSDLYHPI QILADYLTLQ EHYSSLKGLT LSWIGDGNNI LHSIMMSAAK FGMHLQAATP KGYEPDASVT KLAEQYAKEN GTKLLLTNDP LEAAHGGNVL ITDTWISMGQ EEEKKKRLQA FQGYQVTMKT AKVAASDWTF LHCLPRKPEE VDDEVFYSPR SLVFPEAENR KWTIMAVMVS LLTDYSPQLQKPKFHHHHHH

    • Predicted molecular weight

      41 kDa

    • Amino acids

      1 to 354

    • Tags

      His tag C-Terminus

Preparation and Storage

  • Alternative names

    • EC 2.1.3.3
    • MGC129967
    • MGC129968
    • MGC138856
    • OCTD
    • Ornithine Carbamoyltransferase
    • Ornithine carbamoyltransferase mitochondrial
    • Ornithine carbamoyltransferase, mitochondrial
    • Ornithine transcarbamylase
    • Otc
    • OTC_HUMAN
    • OTCase
    see all

  • Tissue specificity

    Mainly expressed in liver and intestinal mucosa.

  • Pathway

    Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.

  • Involvement in disease

    Ornithine carbamoyltransferase deficiency

  • Sequence similarities

    Belongs to the ATCase/OTCase family.

  • Post-translational
    modifications

    Acetylation at Lys-88 negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals.

  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452)
    SDS-PAGE - Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452)
    10-20% acrylamide separation gel showing ab123452 at approximately 40kDa (1µg).
  • Western blot - Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452)
    Western blot - Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452)
    Anti-Ornithine Carbamoyltransferase/OTC antibody (ab86665) at 0.5 µg/ml + Recombinant Human Ornithine Carbamoyltransferase/OTC protein (ab123452) at 0.01 µg

    Secondary
    Goat polyclonal to Rabbit IgG – H&L – Pre-Adsorbed (HRP) at 1/10000 dilution

    Developed using the ECL technique.

    Predicted band size: 40 kDa
    Observed band size: 40 kDa


    Exposure time: 5 minutes

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