Recombinant human Oncostatin M/OSM protein (Active) (ab270077)
Key features and details
- Expression system: HEK 293 cells
- Endotoxin level:
- Active: Yes
- Suitable for: HPLC, MS, SDS-PAGE, Functional Studies, Cell Culture
Preparation and Storage
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Alternative names
- MGC20461
- ONCM_HUMAN
- Oncostatin M
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Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). -
Sequence similarities
Belongs to the LIF/OSM family. -
Cellular localization
Secreted. - Information by UniProt
Images
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Functional Studies - Recombinant human Oncostatin M/OSM protein (Active) (ab270077)
Fully biologically active when compared to standard. Determined by the dose dependant proliferation of TF-1 cell line.
ED50 is ≤ 0.2ng/mL, corresponding to a specific activity of 5.00 x 106 units/mg.
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SDS-PAGE - Recombinant human Oncostatin M/OSM protein (Active) (ab270077) -
HPLC - Recombinant human Oncostatin M/OSM protein (Active) (ab270077)Purity by HPLC ≥95%.
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Mass Spectrometry - Recombinant human Oncostatin M/OSM protein (Active) (ab270077)(M - 2Arg) + 0.8 Da (expected mass after Arg loss due to transpeptidation 21896 Da; +16 Da: Hydroxylation/Oxidation, +32 Da: dioxidation; +203 Da HexNAc, + 365 Da Hex(1)HexNAc(1).
Calc MW is 22208.41 Da.
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Mass Spectrometry - Recombinant human Oncostatin M/OSM protein (Active) (ab270077)(M - 2Arg) + 0.8 Da (expected mass after Arg loss due to transpeptidation 21896 Da; +16 Da: Hydroxylation/Oxidation, +32 Da: dioxidation; +203 Da HexNAc, + 365 Da Hex(1)HexNAc(1)
Calc MW is 22208.41 Da.