Recombinant Human MHC Class II beta protein (Tagged) (ab114224)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: ELISA, SDS-PAGE, WB
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Product name
Recombinant Human MHC Class II beta protein (Tagged) -
Expression system
Wheat germ -
Accession
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Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQGRQECYAFNGT QRFLERYIYNREEYARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRA VPDRVCRHNYELDEAVTLQRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFY PGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYIC QVEHTSLDSPVTVEWKAQSDSAQSKTLTGAGGFVLGLIICGVGIFMHRRS KKVQRGSA -
Predicted molecular weight
54 kDa including tags -
Amino acids
1 to 258 -
Tags
GST tag N-Terminus
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Preparation and Storage
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Alternative names
- DPB1
- HLA-DP
- HLA-DP1B
see all -
Relevance
Major Histocompatibility Class II molecules are primarily expressed on B-cells and antigen presenting cells (APCs). They are composed of two polypeptide chains. These polypeptides (alpha and beta) are about 230 and 240 amino acids long, respectively, and are glycosylated. These polypeptides fold into two separate domains; the non-polymorphic alpha chain and the polymorphic beta chain. The antigen binding region of the molecule is bounded by a beta-pleated sheet on the bottom and two alpha helices on the sides, and is capable of binding (via non-covalent interactions) a small peptide of about 10 amino acids. -
Cellular localization
Cell Membrane
Images
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SDS-PAGE - Recombinant Human MHC Class II beta protein (Tagged) (ab114224)ab114224 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.