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Recombinant Human MGEA5/OGA protein (ab153117)

Key features and details

  • Expression system: Wheat germ
  • Tags: GST tag N-Terminus
  • Suitable for: WB, ELISA

Description

  • Product name

    Recombinant Human MGEA5/OGA protein
    See all MGEA5/OGA proteins and peptides

  • Expression system

    Wheat germ

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAV AGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDD YKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKE VSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITN EIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWT GPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSED STVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSR QVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTT LTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMD TDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTA EPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSI MSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGAND LFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDL IGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPF MQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKK VTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA KMEGFPKDVVILGRSL

    • Amino acids

      1 to 916

    • Tags

      GST tag N-Terminus

Preparation and Storage

  • Alternative names

    • Beta-hexosaminidase
    • Beta-N-acetylglucosaminidase
    • Beta-N-acetylhexosaminidase
    • Bifunctional protein NCOAT
    • HEXC
    • Hyaluronidase in meningioma
    • KIAA0679
    • MEA5
    • Meningioma expressed antigen 5
    • Meningioma-expressed antigen 5
    • MGEA 5
    • Mgea5
    • N-acetyl-beta-D-glucosaminidase
    • N-acetyl-beta-glucosaminidase
    • NCOAT
    • Nuclear cytoplasmic O GlcNAcase and acetyltransferase
    • Nuclear cytoplasmic O-GlcNAcase and acetyltransferase
    • OGA
    • OGA_HUMAN
    • Protein O-GlcNAcase
    see all

  • Function

    Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
    Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

  • Tissue specificity

    Ubiquitous. Shows highest expression in the brain, placenta and pancreas.

  • Sequence similarities

    Belongs to the glycosyl hydrolase 84 family.

  • Post-translational
    modifications

    Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.

  • Cellular localization

    Cytoplasm and Nucleus.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human MGEA5/OGA protein (ab153117)
    SDS-PAGE - Recombinant Human MGEA5/OGA protein (ab153117)
    ab153117 on a 12.5% SDS-PAGE stained with Coomassie Blue.

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