Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant human LTBR protein (Fc Chimera Active) (ab215015)

Key features and details

  • Expression system: CHO cells
  • Purity: >= 98% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: Functional Studies, SDS-PAGE

Description

  • Product name

    Recombinant human LTBR protein (Fc Chimera Active)
    See all LTBR proteins and peptides

  • Biological activity

    Shows the biological function of the LTBR moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

  • Purity

    >= 98 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    CHO cells

  • Accession

    P36941

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      QAVPPYASENQTCRDQEKEYYEPQHRICCSRCPPGTYVSAKCSRIRDTVC ATCAENSYNEHWNYLTICQLCRPCDPVMGLEEIAPCTSKRKTQCRCQPGM FCAAWALECTHCELLSDCPPGTEAELKDEVGKGNNHCVPCKAGHFQNTSS PSARCQPHTRCENQGLVEAAPGTAQSDTTCKNPLEPLPPEMSGTM

    • Predicted molecular weight

      22 kDa

    • Amino acids

      31 to 225

    • Additional sequence information

      Fused to the N-terminus of the Fc region of a mutant human IgG1 (NP_002333.1).

    • Specifications

    Our Abpromise guarantee covers the use of ab215015 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Functional Studies

      SDS-PAGE

    • Form

      Lyophilized

    • Additional notes

      Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: 100% PBS

      Lyophilised from 0.2µm filtered solution.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute at 100 µg/mL in sterile PBS.

    General Info

    • Alternative names

      • CD18
      • D12S370
      • LT beta R
      • LTBETAR
      • Ltbr
      • Lymphotoxin B receptor
      • Lymphotoxin beta receptor
      • Lymphotoxin beta receptor (TNFR superfamily, member 3)
      • Lymphotoxin-beta receptor
      • TNF R III
      • TNF-RIII
      • TNFCR
      • TNFR RP
      • TNFR superfamily member 3
      • TNFR-III
      • TNFR2 RP
      • TNFR2RP
      • TNFR3
      • TNFRII
      • TNFRRP
      • TNFRSF 3
      • TNFRSF3
      • TNR3_HUMAN
      • Tumor necrosis factor C receptor
      • Tumor necrosis factor receptor 2 related protein
      • Tumor necrosis factor receptor 2-related protein
      • Tumor necrosis factor receptor superfamily member 3
      • Tumor necrosis factor receptor superfamily member 3 precursor
      • Tumor necrosis factor receptor type III
      see all

    • Function

      Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

    • Sequence similarities

      Contains 4 TNFR-Cys repeats.

    • Cellular localization

      Membrane.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab215015? Please let us know so that we can cite the reference in this datasheet.

ab215015 has not yet been referenced specifically in any publications.

Preparation and Storage

  • CD18
  • D12S370
  • LT beta R

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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