Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human IL37 protein (ab151873)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Suitable for: HPLC, SDS-PAGE

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C.

    pH: 7.40
    Constituents: 99% Phosphate Buffer, 0.03% DTT, 0.88% Sodium chloride

  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilised protein in 1X PBS. It is not recommended to reconstitute to a concentration less than 100 µg/ml.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days. For long term storage aliquot and store at

    General Info

    • Alternative names

      • FIL1
      • FIL1 zeta
      • FIL1(ZETA)
      • FIL1Z
      • IL 1 zeta
      • IL 1F7
      • IL 1F7b (IL 1H4, IL 1H, IL 1RP1)
      • IL 1H4
      • IL 1RP1
      • IL 1X
      • IL 1X protein
      • IL-1 zeta
      • IL-1F7
      • IL-1H
      • IL-1H4
      • IL-1RP1
      • IL-1X
      • IL-37
      • IL1F7
      • IL1F7 (canonical product IL 1F7b)
      • IL1F7_HUMAN
      • IL1H4
      • IL1RP1
      • Interleukin 1 family member 7
      • interleukin 1 family, member 7 (zeta)
      • Interleukin 1 homolog 4
      • Interleukin 1 related protein
      • Interleukin 1 superfamily z
      • Interleukin 1 zeta
      • Interleukin 37
      • Interleukin-1 family member 7
      • Interleukin-1 homolog 4
      • Interleukin-1 zeta
      • Interleukin-1-related protein
      • Interleukin-23
      see all

    • Function

      Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

    • Tissue specificity

      In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

    • Sequence similarities

      Belongs to the IL-1 family.

    • Post-translational
      modifications

      Proteolytically converted to the mature form by CASP1.

    • Cellular localization

      Cytoplasm > cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
    • Information by UniProt

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

References (0)

Publishing research using ab151873? Please let us know so that we can cite the reference in this datasheet.

ab151873 has not yet been referenced specifically in any publications.

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Alternative products to Recombinant Human IL37 protein (ab151873)

Get resources and offers direct to your inbox Sign up