Astana Biomed Group, an authorized Abcam distributor in Central Asia

Recombinant Human IL-21 protein (Mutant) (ab214135)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 90% SDS-PAGE
  • Endotoxin level:
  • Tags: His tag N-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human IL-21 protein (Mutant)
    See all IL-21 proteins and peptides

  • Purity

    > 90 % SDS-PAGE.

  • Endotoxin level

  • Expression system

    Escherichia coli

  • Accession

    Q9HBE4

  • Protein length

    Full length protein

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Predicted molecular weight

      17 kDa

    • Amino acids

      23 to 155

    • Modifications

      mutated Q138D + Q143D

    • Tags

      His tag N-Terminus

    • Additional sequence information

      Mature form without signal peptide.

    • Specifications

    Our Abpromise guarantee covers the use of ab214135 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      SDS-PAGE

    • Form

      Lyophilized
    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

      Constituent: PBS

    • Reconstitution
      Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

    General Info

    • Alternative names

      • CVID11
      • IL 21
      • IL-21
      • Il21
      • IL21_HUMAN
      • Interleukin 21
      • Interleukin-21
      • interleukin-21 isoform
      • Interleukin21
      • OTTHUMP00000164088
      • Za11
      see all

    • Function

      Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.

    • Tissue specificity

      Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.

    • Sequence similarities

      Belongs to the IL-15/IL-21 family.

    • Cellular localization

      Secreted.
    • Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References (0)

Publishing research using ab214135? Please let us know so that we can cite the reference in this datasheet.

ab214135 has not yet been referenced specifically in any publications.

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

    Constituent: PBS

  • Reconstitution
    Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

Images

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Alternative products to Recombinant Human IL-21 protein (Mutant) (ab214135)

Sign up