Recombinant human IL-17RA Receptor protein (Active) (Biotin) (ab271551)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 80% SDS-PAGE
- Active: Yes
- Tags: Avi tag C-Terminus, Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE
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Product name
Recombinant human IL-17RA Receptor protein (Active) (Biotin)
See all IL-17RA Receptor proteins and peptides -
Biological activity
Active in a IL-17RA:IL-17A binding assay.
100 ng of IL-17A was coated onto a 96-well plate overnight. The indicated amount of ab271551 was added in IL-17 Assay Buffer and allowed to incubate at room temperature for 2 hr. Strep-HRP was added, followed by chemiluminescent substrate and detection.
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Purity
>= 80 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
LRLLDHRALV CSQPGLNCTV KNSTCLDDSW IHPRNLTPSS PKDLQIQLHF AHTQQGDLFP VAHIEWTLQT DASILYLEGA ELSVLQLNTN ERLCVRFEFL SKLRHHHRRW RFTFSHFVVD PDQEYEVTVH HLPKPIPDGD PNHQSKNFLV PDCEHARMKV TTPCMSSGSL WDPNITVETL EAHQLRVSFT LWNESTHYQI LLTSFPHMEN HSCFEHMHHI PAPRPEEFHQ RSNVTLTLRN LKGCCRHQVQ IQPFFSSCLN DCLRHSATVS CPEMPDTPEP IPDYMPLW -
Predicted molecular weight
62 kDa including tags -
Molecular weight information
Protein runs at higher than predicted MW on SDS-PAGE due to glycosylation. -
Amino acids
33 to 320 -
Tags
Avi tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Human IgG1 Fc.
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Conjugation
Biotin
Preparation and Storage
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Alternative names
- CANDF5
- CD217
- CD217 antigen
see all -
Function
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. -
Tissue specificity
Widely expressed. -
Involvement in disease
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
Sequence similarities
Contains 1 SEFIR domain. -
Post-translational
modificationsGlycosylated. -
Cellular localization
Membrane. - Information by UniProt
Images
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Functional Studies - Recombinant Human IL-17RA Receptor protein (Tagged) (Biotin) (ab271551)
Functional analysis of ab271551.
Active in a IL-17RA:IL-17A binding assay.
100 ng of IL-17A was coated onto a 96-well plate overnight. The indicated amount of ab271551 was added in IL-17 Assay Buffer and allowed to incubate at room temperature for 2 hr. Strep-HRP was added, followed by chemiluminescent substrate and detection.
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SDS-PAGE - Recombinant Human IL-17RA Receptor protein (Tagged) (Biotin) (ab271551)SDS-PAGE analysis of ab271551.