Recombinant Human IL-16 protein (ab268661)
Key features and details
- Expression system: Escherichia coli
- Purity: >= 95% SDS-PAGE
- Endotoxin level:
- Suitable for: SDS-PAGE
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Product name
Recombinant Human IL-16 protein
See all IL-16 proteins and peptides -
Purity
>= 95 % SDS-PAGE. -
Endotoxin level
Expression system
Escherichia coliAccession
Protein length
Protein fragmentAnimal free
NoNature
Recombinant-
Species
Human
Specifications
Our Abpromise guarantee covers the use of ab268661 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Applications
SDS-PAGE
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Form
Lyophilized -
Concentration information loading...
Preparation and Storage
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Stability and Storage
Shipped on Dry Ice. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Constituent: PBS
Lyophilized from 0.2 µm filtered solution in PBS. -
ReconstitutionReconstitute in sterile PBS at 5 µg/ml.
General Info
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Alternative names
- HGNC:5980
- HsT19289
- IL-16
see all -
Function
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. -
Tissue specificity
Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation. -
Sequence similarities
Contains 4 PDZ (DHR) domains. -
Post-translational
modificationsIsoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16. -
Cellular localization
Cytoplasm; Cytoplasm. Nucleus and Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human IL-16 protein (ab268661)
ab268661 resolved on a 15% SDS-PAGE gel under reducing conditions.
Stained with coomassie blue.
MW ~13.5 kDa.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
References (0)
ab268661 has not yet been referenced specifically in any publications.
Preparation and Storage
- HGNC:5980
- HsT19289
- IL-16
Images
-
SDS-PAGE - Recombinant Human IL-16 protein (ab268661)
ab268661 resolved on a 15% SDS-PAGE gel under reducing conditions.
Stained with coomassie blue.
MW ~13.5 kDa.