Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Escherichia coli
Purity: >= 98% SDS-PAGE
Active: Yes
Suitable for: Functional Studies, SDS-PAGE

Product name

Recombinant human Granzyme A protein
See all Granzyme A proteins and peptides
Biological activity

Specific Activity: ~110U/µg protein. One unit is defined as the amount of enzyme that hydrolyzes 1nmol Z-Lys-SBzl per min. at 25°C in 0.05M TRIS, pH 8.0, containing 0.15M NaCl, 0.01% Triton X-100 and 0.3mM DTNB.
Purity

>= 98 % SDS-PAGE.
Expression system

Escherichia coli
Accession

P12544
Protein length

Full length protein
Animal free

No
Nature

Recombinant
- Species
  
  Human
- Sequence
  
  IIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTAAHCNLNKRSQV ILGAHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINK YVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKV CNDRNHYNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLCEGVFRGVTSF GLENKCGDPRGPGVYILLSKKHLNWIIMTIKGAV
- Predicted molecular weight
  
  52 kDa
- Amino acids
  
  29 to 262

Alternative names
- CTL tryptase
- CTLA3
- Cytolytic t cell and natural killer cell specific trypsin like serine protease
- Cytotoxic T lymphocyte associated serine esterase 3
- Cytotoxic T lymphocyte proteinase 1
- Cytotoxic T-lymphocyte proteinase 1
- Fragmentin 1
- Fragmentin-1
- GRAA_HUMAN
- Granzyme 1 cytotoxic T lymphocyte associated serine esterase 3
- Granzyme A
- Granzyme A (Cytotoxic T lymphocyte associated serine esterase 3; Hanukah factor serine protease)
- Granzyme A (granzyme 1, cytotoxic T lymphocyte associated serine esterase 3)
- Granzyme A precursor
- Granzyme-1
- GZMA
- H factor
- Hanukah factor serine protease
- Hanukkah factor
- HF
- HFSP
- TSP1
see all
Function

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
Sequence similarities

Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
Cellular localization

Secreted. Cytoplasmic granule.
Target information above from: UniProt accession P12544 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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