Recombinant Human Glypican 3 protein (Tagged) (Biotin) (ab271530)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 71% SDS-PAGE
- Tags: His tag C-Terminus, Avi tag C-Terminus
- Suitable for: SDS-PAGE
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Product name
Recombinant Human Glypican 3 protein (Tagged) (Biotin)
See all Glypican 3 proteins and peptides -
Purity
>= 71 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
QPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCS RKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKN YTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSL FPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQ VTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPC GGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLF STIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLK VAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWN GQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLR TMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLA ELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVH -
Predicted molecular weight
63 kDa -
Amino acids
25 to 559 -
Tags
His tag C-Terminus , Avi tag C-Terminus -
Additional sequence information
Includes alpha and beta subunits.
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Conjugation
Biotin
Preparation and Storage
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Alternative names
- DGSX
- Glypican proteoglycan 3
- Glypican-3 [Precursor]
see all -
Function
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. -
Tissue specificity
Highly expressed in lung, liver and kidney. -
Involvement in disease
Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. -
Sequence similarities
Belongs to the glypican family. -
Cellular localization
Cell membrane and Secreted > extracellular space. - Information by UniProt
Images
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Western blot - Recombinant Human Glypican 3 protein (Tagged) (Biotin) (ab271530)
Recombinant Human Glypican 3 protein (Tagged) (Biotin) (ab271530) used as positive control in WB.
Lane 1: Non-reducing conditions.
Lane 2: Reducing conditions.
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SDS-PAGE - Recombinant Human Glypican 3 protein (Tagged) (Biotin) (ab271530)SDS-PAGE analysis of 7 µg ab271530.