Recombinant human GITR protein (Active) (Biotin) (ab271528)
Key features and details
- Expression system: HEK 293 cells
- Purity: >= 90% SDS-PAGE
- Active: Yes
- Tags: Avi tag C-Terminus, Fc tag C-Terminus
- Suitable for: SDS-PAGE, Functional Studies
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Product name
Recombinant human GITR protein (Active) (Biotin)
See all GITR proteins and peptides -
Biological activity
The GITR:GITRL binding activity was performed in an inhibitor screening assay kit. In a 96-well plate coated with GITRL, ab271528 is incubated, followed by streptavidin-HRP and addition of an HRP substrate. Chemiluminescence produce is measured using a chemiluminescence reader.
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Purity
>= 90 % SDS-PAGE. -
Expression system
HEK 293 cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE -
Predicted molecular weight
43 kDa including tags -
Molecular weight information
This protein runs at a higher molecular weight by SDS-PAGE due to glycosylation. -
Amino acids
26 to 161 -
Tags
Avi tag C-Terminus , Fc tag C-Terminus -
Additional sequence information
Human IgG1 Fc
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Conjugation
Biotin
Preparation and Storage
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Alternative names
- Activation inducible TNFR family receptor
- Activation-inducible TNFR family receptor
- AITR
see all -
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. -
Tissue specificity
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. -
Sequence similarities
Contains 3 TNFR-Cys repeats. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant human GITR protein (Active) (Biotin) (ab271528)
SDS-PAGE analysis of 3 µg ab271528.
This protein runs at a higher molecular weight due to glycosylation.
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Functional Studies - Recombinant human GITR protein (Active) (Biotin) (ab271528)GITRL: GITR-biotin binding.
