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Recombinant human GITR protein (Active) (Biotin) (ab271528)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 90% SDS-PAGE
  • Active: Yes
  • Tags: Avi tag C-Terminus, Fc tag C-Terminus
  • Suitable for: SDS-PAGE, Functional Studies

Description

  • Product name

    Recombinant human GITR protein (Active) (Biotin)
    See all GITR proteins and peptides

  • Biological activity

    The GITR:GITRL binding activity was performed in an inhibitor screening assay kit. In a 96-well plate coated with GITRL, ab271528 is incubated, followed by streptavidin-HRP and addition of an HRP substrate. Chemiluminescence produce is measured using a chemiluminescence reader.

  • Purity

    >= 90 % SDS-PAGE.

  • Expression system

    HEK 293 cells

  • Accession

    Q9Y5U5

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAE

    • Predicted molecular weight

      43 kDa including tags

    • Molecular weight information

      This protein runs at a higher molecular weight by SDS-PAGE due to glycosylation.

    • Amino acids

      26 to 161

    • Tags

      Avi tag C-Terminus , Fc tag C-Terminus

    • Additional sequence information

      Human IgG1 Fc

  • Conjugation

    Biotin

Preparation and Storage

  • Alternative names

    • Activation inducible TNFR family receptor
    • Activation-inducible TNFR family receptor
    • AITR
    • CD357
    • GITR
    • GITR D
    • GITR-D
    • GITRD
    • Glucocorticoid induced TNFR related protein
    • glucocorticoid-induced tnf receptor ligand
    • glucocorticoid-induced tnf receptors ligand
    • Glucocorticoid-induced TNFR-related protein
    • TNF receptor superfamily activation inducible protein
    • TNFRSF 18
    • TNFRSF18
    • TNR18_HUMAN
    • Tumor necrosis factor receptor superfamily member 18
    • Tumor necrosis factor receptor superfamily member 18 precursor
    see all

  • Function

    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

  • Tissue specificity

    Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

  • Sequence similarities

    Contains 3 TNFR-Cys repeats.

  • Cellular localization

    Secreted and Cell membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant human GITR protein (Active) (Biotin) (ab271528)
    SDS-PAGE - Recombinant human GITR protein (Active) (Biotin) (ab271528)

    SDS-PAGE analysis of 3 µg ab271528.

    This protein runs at a higher molecular weight due to glycosylation.

  • Functional Studies - Recombinant human GITR protein (Active) (Biotin) (ab271528)
    Functional Studies - Recombinant human GITR protein (Active) (Biotin) (ab271528)

    GITRL: GITR-biotin binding.

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