Recombinant human FGF9/GAF protein (Animal Free) (ab256004)
Key features and details
- Expression system: Escherichia coli
- Purity: >= 95% SDS-PAGE
- Endotoxin level:
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE
Preparation and Storage
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Alternative names
- FGF 9
- FGF-9
- FGF9
see all -
Function
May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. -
Tissue specificity
Glial cells. -
Involvement in disease
Defects in FGF9 are the cause of multiple synostoses syndrome type 3 (SYNS3) [MIM:612961]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness. -
Sequence similarities
Belongs to the heparin-binding growth factors family. -
Post-translational
modificationsThree molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
N-glycosylated. -
Cellular localization
Secreted. - Information by UniProt
Images
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SDS-PAGE - Recombinant human FGF9 protein (Animal Free) (ab256004)
SDS-PAGE analysis of ab256004 (1 μg) under non-reducing (Lane 1) and reducing (Lane 2) conditions.
4-20% Tris-Glycine gel. Coomassie Blue staining.
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Functional Studies - Recombinant human FGF9 protein (Animal Free) (ab256004)ab256004 induced proliferation of NR6R-3T3 cells.
