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Recombinant human FGF19 protein (ab200246)

Key features and details

  • Expression system: Escherichia coli
  • Purity: > 95% SDS-PAGE
  • Endotoxin level:
  • Active: Yes
  • Suitable for: SDS-PAGE, Functional Studies, HPLC

Preparation and Storage

  • Alternative names

    • FGF 19
    • FGF-19
    • FGF15
    • FGF19
    • FGF19_HUMAN
    • Fibroblast growth factor 15
    • Fibroblast growth factor 19
    see all

  • Function

    Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.

  • Tissue specificity

    Expressed in fetal brain, cartilage, retina, and adult gall bladder.

  • Sequence similarities

    Belongs to the heparin-binding growth factors family.

  • Cellular localization

    Secreted.
  • Information by UniProt

Images

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