Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Expression system: Escherichia coli
Purity: > 95% SDS-PAGE
Endotoxin level:
Active: Yes
Suitable for: SDS-PAGE, Functional Studies, HPLC

Alternative names
- FGF 19
- FGF-19
- FGF15
- FGF19
- FGF19_HUMAN
- Fibroblast growth factor 15
- Fibroblast growth factor 19
see all
Function

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.
Tissue specificity

Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Sequence similarities

Belongs to the heparin-binding growth factors family.
Cellular localization

Secreted.
Target information above from: UniProt accession O95750 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt

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