• Product name

  Recombinant human EREG protein
  See all EREG proteins and peptides

• Biological activity

  The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.

• Purity

  > 95 % SDS-PAGE.
  Greater than 98% by SDS-PAGE and HPLC analyses.
  

• Expression system

  Escherichia coli

• Protein length

  Full length protein

• Animal free

  No

• Nature

  Recombinant

• • Species

    Human

  • Sequence

    MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL

• Alternative names

  • Epiregulin
  • EPR
  • ER

  • Ereg
  • EREG_HUMAN
  • Proepiregulin

  see all

• Function

  May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis.

• Tissue specificity

  In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.

• Sequence similarities

  Contains 1 EGF-like domain.

• Cellular localization

  Cell membrane and Secreted > extracellular space.

• Target information above from: UniProt accession O14944 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt