Recombinant Human Dopamine Transporter protein (ab112352)
Key features and details
- Expression system: Wheat germ
- Tags: GST tag N-Terminus
- Suitable for: SDS-PAGE, ELISA, WB
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Product name
Recombinant Human Dopamine Transporter protein -
Expression system
Wheat germ -
Accession
-
Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
AWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGT TPAAEYFERGVLHLHQSHGIDDLGPPR -
Predicted molecular weight
34 kDa including tags -
Amino acids
161 to 237 -
Tags
GST tag N-Terminus
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Preparation and Storage
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Alternative names
- DA transporter
- DAT
- DAT 1
see all -
Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. -
Involvement in disease
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs. -
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily. -
Cellular localization
Membrane. - Information by UniProt
Images
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SDS-PAGE - Recombinant Human Dopamine Transporter protein (ab112352)ab112352 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.