Recombinant human CDNF protein (ab129133)
Key features and details
- Expression system: Escherichia coli
- Purity: > 98% SDS-PAGE
- Active: Yes
- Suitable for: Functional Studies, SDS-PAGE, HPLC
-
Product name
Recombinant human CDNF protein
See all CDNF proteins and peptides -
Biological activity
Determined by its ability to stimulate the proliferation of Rat C6 cells. The expected ED50 for this effect is 15-25 µg/ml. -
Purity
> 98 % SDS-PAGE.
Purity: > 98% by SDS-PAGE and HPLC analysis. -
Expression system
Escherichia coli -
Accession
-
Protein length
Full length protein -
Animal free
No -
Nature
Recombinant -
-
Species
Human -
Predicted molecular weight
19 kDa -
Amino acids
25 to 178
-
Preparation and Storage
-
Alternative names
- Arginine rich mutated in early stage tumors like 1
- ARMET L1
- ARMET like protein 1
see all -
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. -
Tissue specificity
Widely expressed in neuronal and non-neuronal tissues. In the brain, highest levels in the optic nerve and corpus callosum. -
Sequence similarities
Belongs to the ARMET family. -
Cellular localization
Secreted. - Information by UniProt
