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Recombinant Human CD86 protein (Tagged) (Biotin) (ab271375)

Key features and details

  • Expression system: HEK 293 cells
  • Purity: >= 90% SDS-PAGE
  • Tags: Avi tag C-Terminus, Fc tag C-Terminus
  • Suitable for: SDS-PAGE

Description

  • Product name

    Recombinant Human CD86 protein (Tagged) (Biotin)
    See all CD86 proteins and peptides

  • Purity

    >= 90 % SDS-PAGE.
    =90% purity as measured by gel filtration.

  • Expression system

    HEK 293 cells

  • Accession

    P42081

  • Protein length

    Protein fragment

  • Animal free

    No

  • Nature

    Recombinant

    • Species

      Human

    • Sequence

      LSGAAPLKIQ AYFNETADLP CQFANSQNQS LSELVVFWQD QENLVLNEVY LGKEKFDSVH SKYMGRTSFD SDSWTLRLHN LQIKDKGLYQ CIIHHKKPTG MIRIHQMNSE LSVLANFSQP EIVPISNITE NVYINLTCSS IHGYPEPKKM SVLLRTKNST IEYDGVMQKS QDNVTELYDV SISLSVSFPD VTSNMTIFCI LETDKTRLLS SPFSIELEDP

    • Predicted molecular weight

      54 kDa including tags

    • Molecular weight information

      Protein runs at a higher MW on SDS-PAGE due to glycosylation.

    • Amino acids

      20 to 239

    • Tags

      Avi tag C-Terminus , Fc tag C-Terminus

    • Additional sequence information

      Fc region of human IgG1. Genbank: NM_006889

  • Conjugation

    Biotin

Preparation and Storage

  • Alternative names

    • Activation B7-2 antigen
    • Activation B7-2 antigen 3
    • B-lymphocyte activation antigen B7-2
    • B-lymphocyte activation antigen B7-2 2
    • B7
    • B7 2
    • B7-2
    • B7.2
    • B70
    • B72
    • B72 antigen
    • BU63
    • CD28 antigen ligand 2
    • CD28 antigen ligand 2 2
    • Cd28l2
    • CD28LG2
    • CD86
    • CD86 antigen
    • CD86 antigen (CD28 antigen ligand 2 B7 2 antigen)
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2
    • CD86 molecule
    • CD86_HUMAN
    • CLS1
    • CTLA-4 counter-receptor B7.2
    • CTLA-4 counter-receptor B7.2 2
    • CTLA-4 counter-receptor B7.2 2, 3
    • Early T-cell costimulatory molecule 1
    • ETC-1
    • FUN 1
    • FUN-1
    • FUN1
    • LAB72
    • Ly-58
    • Ly58
    • MB7
    • MB7-2
    • Membrane glycoprotein
    • MGC34413
    • T lymphocyte activation antigen CD86 precursor
    • T-lymphocyte activation antigen CD86
    • TS/A-2
    see all

  • Function

    Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

  • Tissue specificity

    Expressed by activated B-lymphocytes and monocytes.

  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • Post-translational
    modifications

    Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

  • Cellular localization

    Membrane.
  • Information by UniProt

Images

  • SDS-PAGE - Recombinant Human CD86 protein (Tagged) (Biotin) (ab271375)
    SDS-PAGE - Recombinant Human CD86 protein (Tagged) (Biotin) (ab271375)

    SDS-PAGE analysis of 4 μg of ab271375.

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