Recombinant human CD28 protein (Active) (ab245796)
Key features and details
- Expression system: CHO cells
- Purity: > 95% SDS-PAGE
- Active: Yes
- Tags: Fc tag C-Terminus
- Suitable for: Functional Studies, SDS-PAGE, HPLC
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Product name
Recombinant human CD28 protein (Active)
See all CD28 proteins and peptides -
Biological activity
Determined by its ability to bind its principal binding partner (B7-1) in a functional ELISA.
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Purity
> 95 % SDS-PAGE.
>95 % by HPLC analysis. -
Expression system
CHO cells -
Accession
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Protein length
Protein fragment -
Animal free
No -
Nature
Recombinant -
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Species
Human -
Sequence
NKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVV YGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMY PPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPGGPKSCDKTHTCPPCP APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPA PIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHE ALHNHYTQKSLSLSPGK -
Predicted molecular weight
41 kDa -
Tags
Fc tag C-Terminus -
Additional sequence information
Glycosylated, disulfide-linked homodimer of 734 aa residue whose monomer consists of the 134 aa length extracellular portion of CD28 fused to the 231 aa length Fc portion of human IgG1 by two glycines
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Preparation and Storage
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Alternative names
- CD 28
- CD28
- CD28 antigen
see all -
Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. -
Tissue specificity
Expressed in T-cells and plasma cells, but not in less mature B-cells. -
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Cellular localization
Membrane. - Information by UniProt
